National Cancer Institute Central IRB (NCI CIRB) | UCLA Office of the Human Research Protection Program

The Central Institutional Review Board (CIRB) Initiative is sponsored by the National Cancer Institute (NCI) in consultation with the Department of Health and Human Services (DHHS) Office for Human Research Protections (OHRP). The CIRB enables an investigator to enroll patients into adult and pediatric NCI-sponsored clinical trials significantly faster than when employing traditional method of IRB review. The NCI CIRB will serve as the IRB of record for these studies. A detailed description of this process is available on the CIRB website link indicated above.

For more information, email irbreliance@research.ucla.edu.

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Submit a webIRB reliance registration application for each new NCI CIRB study:

Within the application – please provide the CIRB approval letter, protocol, consent template provided by NCI CIRB, and the UCLA site specific consent form.
In parallel please submit all ancillary required reviews.
Once the OHRPP office has received your application, we will verify all local context considerations have been met and issue an External Review Accepted (ERA) letter. This will state that we have completed the local context requirements review and we accept reliance on NCI CIRB.

The NCI CIRB has identified the following three items as local context considerations; where changes and edits to the consent form are allowed:

Local contact information
State and local laws pertaining to informed consent
Institutional policy related to research on NCI-funded studies as allowed in the CIRB Quickguide

The NCI CIRB has set specific consent guidelines, with each section of the model consent form identified, followed by a description of what changes, if any, are permitted.

The UCLA OHRPP office completes our yearly institutional profile along with our local context boilerplate language. The boilerplate language document is our institution’s standard template language that is inserted into our UCLA site specific consent form. This document has been reviewed and approved by the NCI CIRB and additional information on this can be found at the NCI CIRB website.

Please use this checklist which highlights the required UCLA language. More information on completing the NCI CIRB Worksheet’s can be found at the NCI CIRB website.

The UCLA OHRPP will no longer stamp the UCLA version of the consent forms.

Submit amendments for only the following changes:

Changes in study staff, including PI
New or changes in ancillary reviews
New or changes in COIs
Changes in funding

Reminder – If changes to the study do not involve these local context issues, do not submit an amendment. The NCI CIRB is responsible for reviewing and approving all other changes. Any other amendments submitted will be returned and asked to be withdrawn.

Any questions regarding the reliance process, please contact us at irbreliance@research.ucla.edu.

IRB Reliance

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